Gonadotropin Releasing Hormone
GnRH is a neuropeptide that is produced in the hypothalamic
surge and tonic centres. In the male and the female,
the target tissue is the anterior pituitary gland,
specifically Gonadotroph cells. In males and females, secretion of
GnRH results in the release of Follicle Stimulating Hormone and Leutinising
Hormone from the anterior pituitary gland.
GnRH-producing neurons are stimulated into production in response to spontaneous rhythms and by sensory impulses from sensory inputs derived from the external environment. Alterations in the internal conditions of the body can also result in altered GnRH production. For example in some species such as the sheep, there is seasonal sexual activity and the cerebral cortex, hypothalamus, pituitary and testes interact to regulate functions further along the signalling chain.
In females when the oestrogen concentration prior to ovulation reaches a certain threshold, large quantities of GnRH are released in the form of a surge. This results in a corresponding peak in LH that stimulates ovulation. In females this surge centre is often called the preovulatory centre. In males this surge centre becomes inactivated during fetal life due to the brain maturation effects of estradiol (see section below) being able to pass through the blood brain barrier in males, please see the reproductive development of the brain for more details. In males there are between 4-12 GnRH peaks per day. Plasma concentrations of LH peak approximately 10mins post GnRH surge.
For more details regarding the session on Gynecology congress 2020
Email:gynecologycongress@frontierscongress.com
GnRH-producing neurons are stimulated into production in response to spontaneous rhythms and by sensory impulses from sensory inputs derived from the external environment. Alterations in the internal conditions of the body can also result in altered GnRH production. For example in some species such as the sheep, there is seasonal sexual activity and the cerebral cortex, hypothalamus, pituitary and testes interact to regulate functions further along the signalling chain.
In females when the oestrogen concentration prior to ovulation reaches a certain threshold, large quantities of GnRH are released in the form of a surge. This results in a corresponding peak in LH that stimulates ovulation. In females this surge centre is often called the preovulatory centre. In males this surge centre becomes inactivated during fetal life due to the brain maturation effects of estradiol (see section below) being able to pass through the blood brain barrier in males, please see the reproductive development of the brain for more details. In males there are between 4-12 GnRH peaks per day. Plasma concentrations of LH peak approximately 10mins post GnRH surge.
For more details regarding the session on Gynecology congress 2020
Email:gynecologycongress@frontierscongress.com
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